*Original Source: https://en.wikipedia.org/wiki/List_of_airlines_of_the_United_States
| Logo | Airline | Airline Code | Main Hub City | City Codes | Secondary Hubs |
 | Alaska Airlines | AS | Seattle | SEA | Anchorage – ANC Los Angeles – LAX Portland (OR) – PDX San Francisco – SFO San Diego – SAN San Jose (CA) – SJC |
 | Allegiant Air | G4 | Las Vegas | LAS | Bellingham – BLI Cincinnati – CVG Fort Lauderdale – FLL Ft Walton Beach – VPS Knoxville – TYS Los Angeles – LAXMyrtle Beach – MYR Oakland – OAK Orlando/Sanford – ORL Phoenix/Mesa – PHX Pittsburgh – PIT Punta Gorda (FL) – PGD St. Petersburg/Clearwater – TPA/PIE |
 | American Airlines | AA | Dallas-Fort Worth | DFW | Charlotte – CLT Chicago-O’Hare – ORD Los Angeles – LAX Miami – MIA New York-JFK – JFK New York-LaGuardia – LGA Philadelphia – PHL Phoenix-Sky Harbor – PHX Washington-National – WAS |
 | Delta | DL | Atlanta | ATL | Detroit – DTT Los Angeles – LAX Minneapolis/St. Paul – MSP/STP New York-JFK – JFK New York-LaGuardia – LGA Salt Lake City – SLC Seattle/Tacoma – SEA Boston – BOS Cincinnati – CVG Raleigh/Durham – RDU |
 | Frontier Airlines | F9 | Denver | DEN | Atlanta – ATL Austin – AUS/ASQ Chicago-O’Hare – ORD Cincinnati – CVG Cleveland – CLE Las Vegas – LAS Miami – MIA Orlando – ORL Philadelphia – PHL Raleigh/Durham – RDU San Antonio – SAT Trenton – TTN |
 | Hawaiian Airlines | HA | Honolulu | HNL | Kahului – OGG Kailua-Kona – KOA ? Lihue – LIH |
 | JetBlue Airways | B6* | New York – JFK | JFK | Boston – BOS Fort Lauderdale – FLL Long Beach – LGB Orlando – ORL San Juan – SJA |
 | Southwest Airlines | WN | Dallas-Lovefield | DAL | Atlanta – ATL Baltimore – BWI Chicago-Midway – MDW Denver – DEN Houston-Hobby – HOU Las Vegas – LAS Los Angeles – LAX Oakland – OAK Orlando – ORL Phoenix-Sky Harbor – PHX Austin – AUS Fort Lauderdale – FLL Nashville – BNA Sacramento – SAC San Diego – SAN San Jose (CA) – SJC St. Louis – STL Tampa – TPA |
 | Spirit Airlines | NK | Fort Lauderdale | FLL | Detroit – DTT Las Vegas – LAS Atlantic City – ATL Chicago-O’Hare – ORD Dallas/Fort Worth – DFW |
 | Sun Country Airlines/ MN | SY | Minneapolis | MSP | Dallas/Fort Worth – DFW Nashville – BNA Portland (OR) – PDX |
 | United Airlines | UA | Chicago | CHI | Denver – DEN Guam – GUM Houston-Intercontine ntal – HOU Los Angeles – LAX Newark – EWA San Francisco – SFO Washington-Dulles – IAD |